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Joker

This self-styled criminal clown remains as volatile and violent as ever. His showdown with Batman in Arkham Asylum has left him humiliated, angry and thirsty for revenge.

Some form of disease is spreading over the Joker, ravaging his face and body. He has repeatedly refused to be treated by anyone except his special 'nurse' Harley Quinn. The Joker is Batman's #1 villain of all time.